Pyrosequencing at the Health Protection Agency, UK
Abstract number: 902_p700
One of the remits in the Genomics, Proteomics and Bioinformatics Unit (GPBU) of the UK Health Protection Agency is to utilise genomics in infection control by the use of accelerated genomic information and enhanced biotechnological methods to streamline the traditional approaches used in classical molecular genetics to instigate advances in Public Health Protection.
Alteration in gene expression patterns or DNA sequence can have profound effects on biological functions and pathological processes. In GPBU, systems are developed for identifying genetic variations and gene expression and our key developmental objectives are to reformat sequence-based typing into fast, high throughput systems, to explore microbial genome sequences for VNTRs and SNP targets as tools for high resolution strain comparison and to provide tools for molecular-based surveillance of high priority infections.
To this end, Pyrosequencing technology has been evaluated for its utility in SNP characterisation (including antibiotic/drug resistance) and genotyping in Public Health Microbiology in the UK. An overview of applications will be presented including:
Hepatitis C virus
minor genotype analysis
screening from sputum samples
H antigen typing of Salmonella"
|Session name:||XXIst ISTH Congress|
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