HCV viraemia and the degree of hepatic affectation in HCV-HIV co-infected patients
Abstract number: 902_p655
We study the relationship between HCV viraemia (determined by quantitative-PCR) and the degree of hepatic fibrosis in patients with HCV-HIV co-infection prior to treatment.
Materials and Methods:
Twenty-three sera from 23 patients with chronic hepatitis C were studied. The level of RNA HCV was determinate by PCR, previous reverse transcription RNA-DNA complementary (Cobas Amplicor; Roche Diagnostics). The degree of hepatic fibrosis was studied by histological activity rate (HAR-Metavir) in hepatic biopsy.
Nine (39.2%) patients have RNA levels lower than 500 000 IU/mL; five of these have a severe hepatic affectation; three have a severe HAR-Metavir (3) and two have cirrhosis HAR-Metavir (2). In the remaining four patients, three have a moderate HAR-Metavir (2) and one has a slight HAR-Metavir (1). Eight (34.8%) patients have RNA levels from 500 000 to 1 000 000 IU/mL: one patient has a slight HAR-Metavir (1), four patients have a moderate HAR-Metavir (2) and three patients have a severe HAR-Metavir (3). Six (26%) patients have RNA levels higher than 1 000 000 IU/mL: two patients have a slight HAR-Metavir (1), and four patients have a moderate HAR-Metavir (2).
In patients HCV-HIV co-infected there is an association between viraemia and degree of hepatic affectation (HAR-Metavir).
Table 1. Distribution of patients by viremia level and degree of hepatic affection
|Session name:||XXIst ISTH Congress|
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