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HCV viraemia and the degree of hepatic affectation in HCV-HIV co-infected patients

Abstract number: 902_p655

Garcinuño S.

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Objective:

We study the relationship between HCV viraemia (determined by quantitative-PCR) and the degree of hepatic fibrosis in patients with HCV-HIV co-infection prior to treatment.

Materials and Methods:

Twenty-three sera from 23 patients with chronic hepatitis C were studied. The level of RNA HCV was determinate by PCR, previous reverse transcription RNA-DNA complementary (Cobas Amplicor; Roche Diagnostics). The degree of hepatic fibrosis was studied by histological activity rate (HAR-Metavir) in hepatic biopsy.

Results:

Nine (39.2%) patients have RNA levels lower than 500 000 IU/mL; five of these have a severe hepatic affectation; three have a severe HAR-Metavir (3) and two have cirrhosis HAR-Metavir (2). In the remaining four patients, three have a moderate HAR-Metavir (2) and one has a slight HAR-Metavir (1). Eight (34.8%) patients have RNA levels from 500 000 to 1 000 000 IU/mL: one patient has a slight HAR-Metavir (1), four patients have a moderate HAR-Metavir (2) and three patients have a severe HAR-Metavir (3). Six (26%) patients have RNA levels higher than 1 000 000 IU/mL: two patients have a slight HAR-Metavir (1), and four patients have a moderate HAR-Metavir (2).

Conclusion:

In patients HCV-HIV co-infected there is an association between viraemia and degree of hepatic affectation (HAR-Metavir).

Table 1.  Distribution of patients by viremia level and degree of hepatic affection

Q-PCR (IU/mL)HAR-Metavir
Slight (1) No.Moderate (2) No.Severe (3) No.Cirrhosis (4) No. 
0–500,0001332
500,001–1,000,0001430
>1,000,0002400
Spearman's Rho: -0.522
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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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