Gender differences in HIV RNA and CD4 counts, but not in AIDS-defining illnesses and CD4-based HAART initiation threshold, in new entrants to HIV care in Cleveland, Ohio
Abstract number: 902_p652
To examine possible differences between HIV-infected men and women new to HIV care at University Hospitals of Cleveland between 1995 and 2002.
Through database extraction, we identified 1066 patients who sought treatment for the first time at our Special Immunology Unit between 1995 and 2002. Of these, 806 (80.1%) with no history of AIDS-defining illnesses more than 3 months prior to presentation and no prior antiretroviral exposure are included in this analysis. Data were analysed using t-test for independent groups and chi-square (SPSS version 11.0).
Six hundred and thirty-two (78%) of our patients were men. Women had higher CD4 counts and lower HIV RNA than men at baseline (mean: 388 ± 282 vs. 310 ± 242 cells/mL, P = 0.003, and 89 396 ± 168 223 vs. 126 537 ± 200 540 copies/mL, P = 0.048, respectively). The proportion of entrants with CD4 cell counts <200/mL did not differ significantly between sexes (37.8% vs. 30.4%, P = 0.11). There was no difference in the proportion of patients presenting with category C AIDS-defining illnesses, category B symptomatic conditions and STD history between men and women (15.8% vs. 12.0%, P = 0.23; 27.8% vs. 29.8%, P = 0.63; and 17.7% vs. 14.9%, P = 0.42, respectively). Seroprevalence of hepatitis B (HbsAg) was higher in men (8.7% vs. 0.6%, P < 0.001), but there was no difference in hepatitis C Ab (18.8% vs. 15.6%, P = 0.40).
In Cleveland, female new entrants to HIV care had higher CD4 cell counts, lower HIV RNA levels and were less frequently seropositive for hepatitis B infection. Whether women here seek HIV care earlier in the course of disease or whether early markers of HIV disease differ between sexes in this population remains to be determined."
|Session name:||XXIst ISTH Congress|
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