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Gender differences in HIV RNA and CD4 counts, but not in AIDS-defining illnesses and CD4-based HAART initiation threshold, in new entrants to HIV care in Cleveland, Ohio

Abstract number: 902_p652

Loupa C.V.

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Objectives:

To examine possible differences between HIV-infected men and women new to HIV care at University Hospitals of Cleveland between 1995 and 2002.

Methods:

Through database extraction, we identified 1066 patients who sought treatment for the first time at our Special Immunology Unit between 1995 and 2002. Of these, 806 (80.1%) with no history of AIDS-defining illnesses more than 3 months prior to presentation and no prior antiretroviral exposure are included in this analysis. Data were analysed using t-test for independent groups and chi-square (SPSS version 11.0).

Results:

Six hundred and thirty-two (78%) of our patients were men. Women had higher CD4 counts and lower HIV RNA than men at baseline (mean: 388 ± 282 vs. 310 ± 242 cells/mL, P = 0.003, and 89 396 ± 168 223 vs. 126 537 ± 200 540 copies/mL, P = 0.048, respectively). The proportion of entrants with CD4 cell counts <200/mL did not differ significantly between sexes (37.8% vs. 30.4%, P = 0.11). There was no difference in the proportion of patients presenting with category C AIDS-defining illnesses, category B symptomatic conditions and STD history between men and women (15.8% vs. 12.0%, P = 0.23; 27.8% vs. 29.8%, P = 0.63; and 17.7% vs. 14.9%, P = 0.42, respectively). Seroprevalence of hepatitis B (HbsAg) was higher in men (8.7% vs. 0.6%, P < 0.001), but there was no difference in hepatitis C Ab (18.8% vs. 15.6%, P = 0.40).

Conclusions:

In Cleveland, female new entrants to HIV care had higher CD4 cell counts, lower HIV RNA levels and were less frequently seropositive for hepatitis B infection. Whether women here seek HIV care earlier in the course of disease or whether early markers of HIV disease differ between sexes in this population remains to be determined.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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