Effect of an intervention programme on the MRSA outbreak in an Aberdeen infirmary

Abstract number: 902_p571

Lopez-Lozano J.-M.


Aberdeen Royal Infirmary (ARI) has experienced an outbreak of Methicillin resistant Staphylococcus aureus (MRSA) since 1997. We previously reported the relationship between hospital use of third generation cephalosporins (3GC), macrolides (MAC) and fluoroquinolones (FQU) and the emergence of MRSA. In May 2001, an intervention programme was introduced in the intensive care unit (ICU) involving admission screening and body decontamination. This study evaluated the effect of this programme on the overall hospital outbreak.


ARI is a 1200 bed teaching hospital with 16 ICU beds. Monthly nonduplicate MRSA data and antibiotic use data were collected for the ICU beds and the non-ICU beds, for the period January 96 to March 03. Time series dynamic regression models were adjusted to evaluate the intervention effect.


ICU-MRSA evolution preceded the non-ICU MRSA by a 1-month lag. ICU-MRSA was dependent on past ICU-MRSA values as well as lagged ICU use of MAC, TGC and FQU. The intervention decreased the per cent monthly ICU-MRSA by the value 10.6. The impact of the ICU intervention on the non-ICU MRSA was 5.6%, thus breaking the increasing trend of the MRSA epidemic.


The ICU can influence the prevalence of nosocomial infections in the rest of the hospital because of the continuous flux of patients. This study promotes the benefits of interventions other than reducing antimicrobial use in the control of MRSA.

Figure 1.  Monthly %MRSA for ICU and Non-ICU beds. Aberdeen Royal Infirmary, January 1996-March 2003


Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Location: Oxford, UK
Presentation type:
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