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The prevalence of nasal colonisation with MRSA among residents of long-term care facilities in South Korea

Abstract number: 902_p556

Lee Y.-S.

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Objectives:

The long-term care facilities (LTCFs) patients are those with serious underlying disease, poor functional status, wounds such as pressure sores, invasive devices of urinary catheters. Residents of LTCFs are at risk for colonisation with multidrug-resistant bacteria including methicillin resistant S. aureus (MRSA). More than 70% of S. aureus isolated in tertiary hospitals in Korea was methicillin resistant. But the prevalence of antimicrobial resistance data in elderly population has not been known yet, in Korea. To determine the prevalence of nasal MRSA colonisation in LTCFs, we investigated the rates of methicillin resistance among the nasal isolates of S. aureus isolated from provincial hospitals for the elderly.

Methods:

Nasal swab specimens were obtained from 632 patients of eight provincial hospitals for elderly from July to August 2002. Swab specimens were cultured on staphylococcal broth for enrichment, and plated on mannitol salt agar and mannitol salt oxacillin agar which was spplemented with 6 mg/mL of oxacillin. Species were identified by PCR and biochemical test. Antimicrobial susceptibility tests to 12 antibiotics were performed by disc diffusion method, MIC of oxacillin was confirmed by agar dilution method. mecA and mupA were detected by multiplex PCR. PFGE and coagulase typing were performed for molecular epidemiological analysis of isolates.

Results

On admission to the LTCFs, 317 S. aureus (50.2%) were isolated from the specimens and were identified resistant to oxacillin in 64% of them range from 36.6 to 80.0% depends on hospitals. mecA gene was detected in all tested 233 MRSA isolates with MICs of 16 to >128 mg/mL. Twenty-three isolates of MRSA were mupirocin resistant with mupA gene and MICs of >1024 mg/mL. The majority of those showed closely genetic relatedness with more than 75% in PFGE and coagulase type II.

Conclusions:

Methicillin resistance of S. aureus isolates in provincial hospitals for the elderly was very high (64%). This study suggests that the importance of infection control programmes in preventing the spread of MRSA in LTCFs should be encouraged.

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Session Details

Date: 01/08/2007
Time: 00:00-00:00
Session name: XXIst ISTH Congress
Subject:
Location: Oxford, UK
Presentation type:
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