The 3rd highest ranked Allergy journal in the world!

Clinical & Experimental Allergy

The Official Journal of the British Society for Allergy & Clinical Immunology

Edited by:
A.J Wardlaw and S.T. Holgate

ISI Journal Citation Reports® Ranking: 2007: 3/17 (Allergy); 32/119 (Immunology)
Impact Factor: 3.729

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Clinical and Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field - we also consider short "hot topic" papers for fast-tracking.  Truly international in appeal, CEA publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.

Clinical and Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms.

Clinical and Experimental Allergy Reviews is a supplement series publishing the edited proceedings of international meetings and sponsored symposia, position papers, guidelines, special reports, and so on. It is allied to Clinical and Experimental Allergy and included with every subscription to the primary research journal.

TopNews and Announcements

• Submit your article online at Manuscript Central  
• Early View: access articles online before print publication
• CEA online subscribers can also receive CEA Reviews
• In response to the increasing number of quality submissions, since 1996 the journal's size has increased by over 30%!

Annual Meeting of the British Society for Allergy and Clinical Immunology
The British Society for Allergy and Clinical Immunology will once again be hosting its scientific annual meeting in Nottingham, UK from 29th June -1st July, 2009.  For further details and to see a copy of the programme please visit www.bsaci.org (or visit the Annual Meeting homepage here) 

Exclusive Conference celebrating 25 years of Clinical and Experimental Allergy.
"Looking back a little: looking forward a lot"!
The BSACI are pleased to announce that we will be hosting an exclusive conference celebrating 25 years of Clinical and Experimental Allergy.  This event is being held to honour Professor Stephen Holgate and Professor Barry Kay who will be retiring as Editors of Clinical and Experimental Allergy after 25 years at the helm.  To celebrate the editorships of both men the BSACI are holding this tribute to showcase the journal and what it has achieved over the years.

This prestigious event will take place on the 8th December 2008 at the Royal Society of Medicine, London

For further details and to see a copy of the programme please visit www.bsaci.org
Free Access in the Developing World
Free online access to this journal is available within institutions in the developing world through the HINARI  initiative with the World Health Organization (WHO). 

Online Open
Authors of articles in this journal can now choose to make their articles open access and available free for all readers through the payment of an author fee. Read more.

Genetic association studies

Papers reporting genetic association studies will be expected to conform to the guidelines set out by Hall and Blakey (Hall IP, Blakey JD. Thorax 2005; 60:357-9.)

 

NIH Public Access Mandate
For those interested in the Wiley-Blackwell policy on the NIH Public Access Mandate,  please visit our policy statement. 

 

TopHighlights

Read these articles free online:

Volume 37, Issue 5 May 2007

Food anaphylaxis

Julie Wang and Hugh A. Sampson

Anaphylaxis is a life-threatening allergic reaction, and food is one of the most common responsible allergens in the outpatient setting. The prevalence of food-induced anaphylaxis has been steadily rising. Education regarding food allergen avoidance is crucial as most of the fatal reactions occurred in those with known food allergies. The lack of a consensus definition for anaphylaxis has made its diagnosis difficult. Symptoms affect multiple organ systems and include pruritus, urticaria, angioedema, vomiting, diarrhoea, abdominal cramps, respiratory difficulty, wheezing, hypotension, and shock. Prompt recognition of anaphylaxis is essential as delayed treatment has been associated with fatalities. Although epinephrine is accepted as the treatment of choice, timely administration does not always occur, partly due to a lack of awareness of the diagnostic criteria. Several novel tools are currently being investigated, which will potentially aid in the diagnosis and treatment of food-induced anaphylaxis.

State of the Art Review

Volume 37, Issue 4 April 2007

The asthma-obesity link in childhood: open questions,complex evidence, a few answers only

P. M. Matricardi, C. Gr¨¹ber, U. Wahn and S. Lau

Obesity and asthma are public health priorities in developed countries. Genes which may contribute to the control of both conditions include those encoding for the ¦Â2-adrenergic receptor, tumour necrosis factor-¦Á (TNF-¦Á) and the insulin-like growth factor 1 (IGF-1). Prospective studies consistently supported a link between obesity and reported wheezing or asthma diagnosis in children. However, there are still no clear explanations for such a link. On one hand, overweight asthmatic children may perceive their asthma as worse. On the other hand, atopic sensitization and bronchial hyper-reactivity do not explain the observed associations. After puberty, the association between asthma and obesity tends to be stronger in girls than in boys. It is conceivable that severe obesity in adolescent females may aggravate asthma through mechanisms different from those linking prepubertal obesity to unremitting asthma in males. Future studies should therefore address multiple age- and genderspecific hypotheses about the mechanisms that link obesity to asthma throughout childhood.

Volume 37, Issue 5 May 2007

BSACI guidelines for the management of chronic urticaria and angio-oedema

R. J. Powell, G.L. Du Toit, N. Siddique, S.C. Leech, T.A. Dixon, A.T. Clark, R. Mirakian, S.M. Walker, P.A.J. Huber and S.M. Nasser

This guidance for the management of patients with chronic urticaria and angio-oedema has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a web-based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking a consensus was reached by the experts on the committee. Included in this guideline are clinical classification, aetiology, diagnosis, investigations, treatment guidance with special sections on children with urticaria, and the use of antihistamines in women who are pregnant or breastfeeding. Finally, we have made recommendations for potential areas of future research.

Volume 36, Issue 3 March 2006

Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferongamma-and interleukin-10-production

L. Cosmi, V. Santarlasci, R. Angeli, F. Liotta, L. Maggi, F. Frosali, O. Rossi,P. Falagiani, G. Riva, S. Romagnani, F. Annunziato and E. Maggi

Background The clinical efficacy and safety of sublingual immunotherapy (SLIT) for aeroallergens has been demonstrated in several trials, whereas the immunological changes induced by this treatment, which may account for the clinical improvement, are still unclear.

Objective To investigate the effects of a successful SLIT on the in vitro allergen-driven T cell response and cytokine secretion as well as on the serum levels of chemokines and of IgE, IgG1 and IgG4 antibodies (Abs).