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Acta Physiologica 2013; Volume 207, Supplement 694
92nd Annual Meeting of the German Physiological Society
3/2/2013-3/5/2013
Heidelberg, Germany
DENDRITIC CALCIUM NONLINEARITIES SWITCH THE DIRECTION OF SYNAPTIC PLASTICITY IN FAST-SPIKING INTERNEURONS
Abstract number: S33
Camiré
1
O.,
Topolnik
1
*L.
1
Dept. Biochemistry, Microbiology and Bio-informatics, Université Laval, Axis of Cellular and Molecular Neuroscience, IUSMQ, Québec, Canada
Dendritic calcium nonlinearities allow neuronal coincidence detection and site-specific plasticity. Here, we report a novel type of calcium nonlinearities at synapses lacking the GluA2 AMPA subtype of glutamate receptors. In hippocampal fast-spiking interneurons, synaptically evoked supralinear calcium events required calcium entry through AMPA receptors with a subsequent calcium release from internal stores, providing the metaplastic switch necessary for the bidirectional control of synaptic efficacy at excitatory synapses.
To cite this abstract, please use the following information:
Acta Physiologica 2013; Volume 207, Supplement 694 :S33