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Acta Physiologica 2013; Volume 207, Supplement 694
92nd Annual Meeting of the German Physiological Society
3/2/2013-3/5/2013
Heidelberg, Germany
SOMATOSTATIN-POSITIVE INTERNEURONS IN THE DENTATE GYRUS ENHANCE MEMORY PRECISION
Abstract number: S29
Cole
1
*K. L. H., Murray
1
A. J., Ansel
1
L., Foggetti
1
A., Riedel
1
G.,
Wulff
1
*P.
1
Institute of Medical Sciences, University of Aberdeen, United Kingdom
2
Institute of Physiology, University of Kiel, Germany
Granule cells of the dentate gyrus form the input stage of the hippocampus. They collect, process and re-code multi-modal sensory input from the entorhinal cortex and feed it into downstream hippocampal sub-regions. Hilar somatostatin-immunoreactive interneurons control granule cell activity through feed-back inhibition. These interneurons form synapses onto granule cell dendrites in close proximity to perforant path inputs suggesting that they might regulate the processing of information from the entorhinal cortex. Here we probe the relevance of this feed-back control for dentate gyrus-dependent behaviour by functional inactivation.
To cite this abstract, please use the following information:
Acta Physiologica 2013; Volume 207, Supplement 694 :S29