An increased oxidative stress may be a relevant cause of inflammatory organ damage or neoplasia in humans. Efficient anti-oxidative systems are thus essential to prevent tissue damage. In plasma, proteins proved to be the first line of defence against Reactive Oxygen Species (ROS) and albumin has a key role in this antioxidant function. Moreover albumin is identified as the major transport protein in blood plasma for many compounds including fatty acids, hormones, bilirubin, ions, and many drugs. Saturated and unsaturated acylethanolamides (NAEs) are almost ubiquitary molecules and are physiologically present in many tissues, including blood and brain, where they show anti-inflammatory and neuroprotective properties. In the present study the binding of three different NAEs to bovine serum albumin (BSA) and their effect on oxidative modifications of BSA induced by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) were investigated by fluorescence spectroscopy. The experimental data reveal that NAEs could inhibit AAPH-induced oxidative modifications of BSA and the results are discussed in comparison with those obtained with human serum albumin.