Students find physiology difficult to learn because it shows special challenges due to the fact that many topics contain temporal elements where processes develop over time and among them there are highly structured interactions. In the last years the improvements in information and communication technology (ICT) allowed the development of new methods in teaching and learning. Into the framework of the "computer-supported collaborative learning" (CSCL), a new learning approach that use modern technology, have been developed a web-based platform aimed to deliver contents through passive and interactive supports, to provide an integrative access to resources among different preclinical and clinical disciplines, to provide tools to students for self evaluation and to offer instruments to teachers to create specific learning and examination path. Furthermore in the physiology courses have also been observed a progressive and significant decrease in both animal- and in vitro-based laboratories that many generation of students found advantageous to reinforce the physiological concepts acquired during lectures and from textbooks. To this purpose an integrated and interactive series of virtual laboratories of physiology, embracing also newly developed methods, have also been implemented . The first results of this program indicate that physiological education can be very effective by the use of web-based activities in enhancing student learning and complementing teacher's lectures.