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Acta Physiologica 2012; Volume 206, Supplement 693
Joint FEPS and Spanish Physiological Society Scientific Congress 2012
9/8/2012-9/11/2012
Santiago de Compostela, Spain
MELATONIN ADMINISTRATION AMELIORATES SLEEP QUALITY AND MOOD STATUS, BUT REDUCES THE OXIDATIVE STRESS IN PATIENTS WITH FIBROMYALGIA
Abstract number: P183
Garrido1 M, Barriga1 C, Rodriguez1 AB
1Physiology, University of Extremadura
Objectives:
To evaluate the effect of the administration of different doses of melatonin on sleep, mood and antioxidant status, as well as determining the urinary cortisol and 6-sulfatoxymelatonin (a-MT6s) levels in patients with fibromyalgia.
Materials:
The study was carried out in 18 middle-aged (45-55 yr-old) women with fibromyalgia. Three doses of melatonin (3 mg/day, 6 mg/day and 9 mg/day) were tested, each dose being assayed in 6 patients. Each group of patients took a pill daily at night during 1 week. Actigraphic monitoring was used to record and display the temporal patterns of the individuals' activity and rest. Analogue visual scales were performed to evaluate subjects' mood status. Urinary total antioxidant capacity was analyzed using a colorimetric assay kit, while urinary cortisol and a-MT6s levels were measured using ELISA kits. Both first-void morning urine and urine at 20:00 h were collected in basal conditions and the last day after each treatment. Sleep parameters were also measured in basal conditions and daily during each treatment. Patients were asked to rate how they were feeling on a psychological test in basal conditions and the last day after each treatment.
Results:
Urinary cortisol and aMT6-s levels were decreased and increased, respectively, after the ingestion of 3 mg, 6 mg and 9 mg of melatonin. Urinary total antioxidant capacity increased after the intake of 9 mg of melatonin. Related to sleep parameters, total nocturnal activity diminished after the three doses assayed. Number of awakenings was decreased after the ingestion of 6 mg and 9 mg of melatonin, whereas the sleep efficiency ameliorated with a dose of 9 mg. Mood status was enhanced after all doses of melatonin assayed.
Conclusions:
The administration of melatonin, at any dose assayed, ameliorates some disorders closely related to fibromyalgia, such as poor sleep quality, mood disturbances and oxidative stress, the effect being dose-dependent.
Funded by Gobierno de Extremadura (Re: GRU10003) and Angelini Farmacéutica S.L.
To cite this abstract, please use the following information:
Acta Physiologica 2012; Volume 206, Supplement 693 :P183