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Acta Physiologica 2012; Volume 206, Supplement 693
Joint FEPS and Spanish Physiological Society Scientific Congress 2012
9/8/2012-9/11/2012
Santiago de Compostela, Spain
ADIPOSE TISSUE EXCESS HAS NEGATIVE EFFECTS ON SLEEP/WAKE CYCLE IN RATS
Abstract number: P169
Bravo1 R, Franco2 L, Cubero3 J, Rodriguez4 A, Galan2 C, Jarne5 C, Barriga2 C
1Department of Physiology. Chrononutrition Laboratory., University of Extremadura. Faculty of Science,
2Department of Physiology. Chrononutrition Laboratory., University of Extremadura. Faculty of Science.,
3Science Education Area. Health Education Laboratory., University of Extremadura. Faculty of Education.,
4Department of Physiology. Chrononutrition Laboratory, University of Extremadura. Faculty of Science.,
5YSONUT Laboratories, YSONUT Laboratories
Objectives:
Our aim was to evaluate if a hypercaloric diet can increase body weight causing negative consequences on activity/inactivity circadian rhythm.
Materials:
16 Wistar rats were fed with a hypercaloric diet (Panlab ©) and 6 control rats were fed with standard food. Animals were kept under constant 12:12 h light/dark cycle, fed ad libitum and housed in separated cages equipped for activity recording. Software Das 24 © was used to log activity in the computer to be able to analyze data with Ritme © software.
Results:
After four months of hypercaloric diet animals showed an increase in their body mass with respect to control group (p<0.001). Sleep activity (p<0.05), awake activity (p<0.001), mesor (p<0.05) and amplitude (p<0.001) became worse as they get fatter. Also acrophase showed a trend to get an advanced phase (p<0.05). Likewise, rhythm fragmentation was higher: interdaily stability decreased (p<0.05) and intradaily variability increased (p<0.01) during the 16 weeks . Control rats did not show these alterations.
Conclusions:
Adiposity excess has negative effects on sleep in rats increasing sleep activity during light hours. This study has been supported by Junta de Extremadura (Fondos FEDER) and YSONUT Laboratories
To cite this abstract, please use the following information:
Acta Physiologica 2012; Volume 206, Supplement 693 :P169