The continued occurrence of occupational Aluminum overexposure and Aluminum poisoning in the World remains a serious problem despite awareness of its adverse health effects.

Urban water supplies may contain a greater concentration because water is usually treated with aluminum before becoming part of the supply. Subsequent purification processes that remove organic compounds take away many of the same compounds that bind the element in its free state, further increasing aluminum concentration.

Aluminum is known for its toxicity and was observed by its presence in dialysis fluids in patients with renal failure and drinking water.

Among all the organs which Aluminium has its toxic effects, the brain is the most sensitive to these effects. It may also affect brain function by interfering with neurotransmitter release and synapse formation and many different areas of the brain including the cerebral cortex, cerebellum and hippocampus.

Aluminium is a potent neurotoxin and has been associated with Alzheimer's disease (AD) causality for decades.

Prolonged aluminium exposure induces oxidative stress and increases amyloid beta levels in vivo

Keywords: 

Aluminium, Al toxicity, Alzheimer disease