Question: 

It is known, that the haemorheological parameter red cell deformability is altered in HIV patients. Recent studies refer to reduced red cell deformability. Endurance training seems to have a positive impact on the physical perceived exertion. We asked whether moderate endurance training over terms of four months can influence red cell deformability and red cell sensitivity.

Methodology: 

12 male HIV patients (age: 40±8 years, BMI: 23.3±3 kg/m²) participated in the study. At the beginning and end of the training intervention the participants passed a treadmill step test. Immediately before and after the test capillary blood was taken from the ear lap and analyzed with the LORCA (laser assisted optical rotational cell analyzer). Here the red cells were measured under basal (0.3 Pa) and maximal (50 Pa) conditions. Shear rate at 50% of the maximal elongation is verified as the red cell sensitivity.

Results: 

After the training intervention higher shear rates have been proven at maximal shear rates. In basal shear rates no differences were identified. The red cell sensitivity reduced significantly at basal and maximal conditions.

Conclusion: 

The changes in red cell deformability and red cell sensitivity confirm a decrease of the red cell rigidity. Medication by the HAART therapy and the impact of oxidative stress during physical activity must be considered in the assessment of the present results.