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Acta Physiologica 2012; Volume 204, Supplement 689
91st Annual Meeting of The German Physiological Society
3/22/2012-3/25/2012
Dresden, Germany
EFFECTS OF GUM ARABIC (ACACIASENEGAL) ON RENAL FUNCTION IN DIABETIC MICE
Abstract number: P094
Umbach1 *A., Nasir1 O., Rexhepaj1 R., Ackermann1 T., Bhandaru1 M., Ebrahim1 A., Artunc2 F., Kempe1 D., Puchchakayala1 G., Siraskar1 B., Foller1 M., Saeed3 A., Lang1 F.
1University of Tbingen, Department of Physiology, Tbingen, Germany
2University of Tbingen, Department of Internal Medicine, Tbingen, Germany
3University of Khartoum, Department of Physiology, Khartoum, Sudan
Background/Aims:
Gum arabic (GA) is a Ca2+-, Mg2+- and K+-rich dietary fiber used for the treatment of patients with chronic kidney disease in Middle Eastern countries. In healthy mice, GA treatment increases creatinine clearance, renal ADH excretion, as well as intestinal and renal excretion of Mg2+ and Ca2+. GA decreases plasma Pi concentration, urinary Pi and Na+ excretion. The present study explored the effects of GA on renal function in diabetic mice.
Methods:
Metabolic cage experiments were performed in Akita mice (akita+/), which spontaneously develop insulin deficiency and thus hyperglycemia. Plasma and urinary concentrations of Na+, K+ and Ca2+ were measured by flame photometry (AFM 5051, Eppendorf, Germany), creatinine by the Jaffé method, phosphate photometrically, urea by an enzymatic method, glucose utilizing a glucometer and an enzymatic kit, aldosterone using a RIA, urinary albumin fluorometrically, and the blood pressure by the tail cuff method.
Results:
GA (10% in drinking water) significantly increased urinary excretion of Ca2+ and significantly decreased plasma phosphate and urea concentrations, urinary flow rate, urinary Na+, phosphate and glucose excretion, blood pressure and proteinuria.
Conclusions:
GA treatment decreases blood pressure and proteinuria in diabetic mice and may thus prove beneficial in diabetic nephropathy.
To cite this abstract, please use the following information:
Acta Physiologica 2012; Volume 204, Supplement 689 :P094