Oxidative stress is involved in retinal degeneration induced by bright continuous light (BCL) exposure. Here we report data showing the protective effect of intravitreally released antioxidant agents (saffron extract and nanoceria-particles). The experimental protocol includes two different techniques:1) Intravitreal injection of nanoceria-particles (2ml) in the right eye 2) Elvax polymer loaded with saffron extract and inserted into the vitreal cavity of the right eye. The fellow eye was used as an internal control. Light-induced damage: after three weeks the animals were exposed to (1000 lux) light for 24h. Functional assessment: Electroretinogram (ERG) was recorded 1 week after light damage from the right and left eye. Morphological analysis: in retinal cryosectioned slices (20 mm) we measured outer nuclear layer (ONL) thickness and immunostained for inflammatory markers. Results: The ERG recorded from the right eye (injected with the CeO2) is higher compared to the left eye while in the Elvax protocol the ERG amplitude is almost comparable in both eyes. Accordingly the outer nuclear layer of the right eye is better preserved in the nanoceria experiment than in the saffron one. Our preliminary results demonstrate that while nanoparticles protect photoreceptors from light damage, maintaining both morphology and function, saffron released by Elvax doesn't present the same efficacy. The two possible ways of action are under analysis.