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Acta Physiologica 2011; Volume 202, Supplement 685
Scandinavian Physiological Society's Annual Meeting
8/12/2011-8/14/2011
Bergen, Norway
EFFECTS OF INTRAVENOUSLY ADMINISTERED NANOPARTICLES ON ARTERIAL BLOOD PRESSURE AND HEART RATE IN RATS
Abstract number: 6.1.4
VLASOVA1 MA, RIIKONEN1 J, RAULA1 J, KAUPPINEN1 E, LOBACH1 AS, ELETSKII1 AV, SALONEN1 J, LEHTO1 VP, HERZIG1 KH, JARVINEN1 K
1A.I.Virtanen institute and School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211, Kuopio, Finland; Email: [email protected]
Aims:
To examine the effects of drug-free nanoparticles on the mean arterial pressure (MAP) and heart rate (HR) in conscious rats after an intravenous bolus injection.
Materials & Methods:
Cardiovascular parameters in conscious rats were monitored with radiotelemetry system. Porous silicon nanoparticles with three different surface chemistries, thermal hydrocarbonization (THCPSi), thermal carbonization (TCPSi) and chemical oxidation (COPSi), Eudragit nanoparticles showing different solubility properties (Eudragit®L100, Eudragit®RSPO and Eudragit® E100) and single walled carbon nanotubes (SWCNT) were tested.
Results:
Intravenous bolus injection (5 mg/rat) of THCPSi nanoparticles, Eudragit® E100 nanoparticles and SWCNT bundles caused a prolonged decrease of MAP and a significant increase in HR from 4 to 9 hours in a dose dependent manner. The corresponding injection of COPSi, Eudragit® RSPO nanoparticles did not affect MAP.
Conclusion:
The results demonstrate that nanoparticles themselves can affect MAP and HR. The mechanisms remain unclear but hydrophobicity of the nanoparticles and shear stress-induced vasodilation might contribute to this phenomenon.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 202, Supplement 685 :6.1.4