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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey
SEVERITY OF ACNE VULGARIS IS ASSOCIATED WITH AN INSULIN-LIKE GROWTH FACTOR-I GENE POLYMORPHISM
Abstract number: PC308
Tasli1 Levent, Turgut2 Sebahat, Kacar1 Nida, Ayada2 Ceylan, Coban1 Melis, Akcilar2 Raziye, Ergin1 Seniz
1Department Of Dermatology, Faculty of Medicine, University of Pamukkale, Denizli, Turkey
2Department of Physiology, Faculty of Medicine, University of Pamukkale, Denizli, Turkey
Objective:
Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin-like growth factor-I (IGF-I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF-I (CA) polymorphism and circulating IGF-I levels in adults has been reported. The aim of our study was to investigate for the first time whether IGF-I (CA) polymorphism might be involved in the pathogenesis of acne.
Methods:
We included 115 acne patients and 117 healthy subjects to the study. The clinical grade of acne was assessed based on the Global Acne Grading System. Participants were questioned about diabetes mellitus, PCOS, and other systemic disease. We searched for the IGF-I (CA) 19 polymorphism in this study. IGF-I (CA) 19 polymorphism was performed by polymerase chain reaction.
Results:
We categorized the IGF-I (CA) 19 polymorphism area into 3 groups as lower than 192 bp, 192194 bp, and higher than 194 bp. We found that the frequency of genotype IGF-1(CA)19 gene was significantly different between control and acne patients (P=0.0002). A significant association between IGF-I (CA) genotypes and severity of acne was found (P = 0.015). No significant difference was found between male and female patients (P>0.05).
Conclusions:
Our results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC308