Objective: 

Transforming growth factor (TGF beta) is a growth factor included in the mechanisms of wound repair and healing that follow inflammatory processes. The objective of this study was to examine the effects of interactions between exogenous TGF beta and antioxidant status in the process of oral wound repair on different days.

Methods: 

Five-month-old New Zealand albino male rabbits were used for this study. Animal experimentation was carried out according to Gazi University Animal Ethics Committee Regulations (21.10.2008/ 92-15912). A surgical incision was made in the right mandibula diestema region of the rabbits, which were then divided into controls and TGF beta 1 implanted groups. Glutathione (GSH), ascorbic acid (AA) levels and superoxide dismutase (SOD) activity which are important antioxidants were measured spectrophotometrically.

Results: 

In the TGF beta 1 implanted groups, SOD activity significantly increased in comparison with those of the control groups on the 1st, 3rd, 5th days after wounding. However, on the 1st day after wounding, the GSH levels significantly decreased in TGF beta 1 implanted group compared to control. Although in the TGF beta 1 implanted groups AA levels decreased in 1st day and 5th days after wounding, on the 3rd day after wounding AA level was found increased comparison with control.

Conclusions: 

TGF beta 1 may play a potentially effective role for antioxidant status by promoting inflammatory response and oxidative events in after days of wounding.