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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


ANTIOXIDANT STATUES IN SENILE MACULAR DEGENERATION
Abstract number: PC287

Yalin1 Serap, Hatungil2 Rezan, Buyukbozat1 Koray, Berkoz1 Mehmet, Comelekoglu2 Ülkü, Eroglu1 Pelin

1Mersin University, Faculty of Pharmacy
2Mersin University, Faculty of Medicine

Objective: 

Age related macular degeneration (AMD) is a medical condition, which usually affects elder adults that result in a loss of vision in the macula because of damage to the retina. It occurs in dry and wet forms. It is a major cause of visual impairment in elder adults. AMD can make it difficult or impossible to read or recognize faces, although enough peripheral vision remains to allow other activities of daily life.

Methods: 

In this study, we investigated the relationship between blood antioxidant enzymes and AMD. A total of 43 volunteers as 23 AMD patients and 20 control group were included to the study. Blood samples taken from the both groups and the plasma were separated by centrifugation. The paraoxonase, arylesterase and protein carbonyl group levels were measured by using biochemical methods.

Results: 

The paraoxonase and arylesterase enzyme activities were found to be significantly lower in the AMD patients when compared to control group. Whereas protein carbonyl groups of AMD patients were significantly higher than the control group.

Conclusions: 

According to results, there is relationship between AMD and antioxidant enzymes and it may be suggested that antioxidant enzymes may be effective on the pathogenesis of AMD.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC287

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