Objective: 

Oxidative stress can be defined as a disruption of redox homeostasis or all the oxidative damages as a result of an overproduction of reactive oxygen species or a reduction in the effectiveness of antioxidant systems in the cell or whole organism, or both. Postprandial dismetabolism is an increasingly common problem in developed countries. The objective of the study was the evaluation of the metabolic changes caused by acute exercise on oxidant/antioxidant levels in postprandial dismetabolism.

Methods: 

The experiment was performed on seven groups (n = 10 animals per group) of male Wistar rats, weighing 200±30 g, in which parameters of oxidative stress were determined: malondialdehyde as a parameter and prooxidant status and free SH groups as markers of antioxidant capacity in relation to exercise. Postprandial dismetabolism was simulated by intraperitoneal injection of 2 ml 33% glucose, respectively the administration of 2 ml of animal fat by feeding tube. Physical effort has been done using the treadmill.

Results: 

An increase in malondialdehyde levels was observed after all types of meals, with the decrease of SH groups levels after effort. The correlation between increased malondialdehyde and decreased SH levels was higher with the increased oxidative stress levels.

Conclusions: 

Postprandial hyperglycemia and hyperlipaemia leads to increased oxidative stress. Acute postprandial exercise increases oxidative stress and reduces antoxidants levels that appear after a normal lunch, also in the case of hyperglycemic or hyperlipemic lunches.