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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey
THE EFFECTS OF PHENYTOIN AND LAMOTRIGINE ON LIPID PEROXIDATION LEVELS OF BRAIN TISSUE IN OFFSPRINGS OF EPILEPTIC RATS
Abstract number: PC268
Soysal1 Handan, Doan2 Zümrüt, Turkoz3 Yusuf, Ekinci2 Nihat, Kamisli4 Özden
1Medicine Faculty Departments of Anatomy, Adiyaman University, Adiyaman, Turkey
2Medicine Faculty Departments of Anatomy, Inonu University, Malatya, Turkey
3Medicine Faculty Departments of Medical Biochemistry, Inonu University, Malatya, Turkey
4Medicine Faculty Departments of Neurology, Inonu University, Malatya, Turkey
Objective:
Comparison of effects of lamotrigine and phenytoin on lipid peroxidation of brain tissue in offspring of epileptic rats.
Methods:
One hundred and twenty-seven Wistar-Albino offspring rats were used in the study. Acute epileptic seizures were produced by an experimental epilepsy model at the 13th day of pregnancy. Lamotrigine (2 mg/kg) and phenytoin (25 mg/kg) were administrated to pregnant rats intraperitoneally at each day of pregnancy period. We measured the MDA levels of brain tissue in offspring rats at 0th, 21th, and 38th days after the birth.
Results:
MDA levels of experimental epilepsy group were significantly higher compared with control group (p<0.05). While phenytoin significantly reduced brain MDA levels in offsprings of pregnant rats (p<0.05), lamotrigine significantly elevated brain MDA levels (p<0.05).
Conclusions:
We suggest that lipid peroxidation plays an important role in the pathogenesis of experimental epilepsy and phenytoin showed protective effect on brain tissue by reducing lipid peroxidation.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC268