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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


EFFECT OF COENZIM Q-10 ON THE LEVEL OF TOTAL LIPID, TOTAL CHOLESTEROL AND FATTY ACIDS IN THE RAT BRAIN
Abstract number: PC257

Akkaya1 Hatice, Celik2 Sait, Ozkaya3 Ahmet, Yilmaz4 Okkes

1Experimental Research Center, Faculty of Medicine, University of Yeditepe, Istanbul, Turkey
2Usak University Rectorship, Usak, Turkey
3Department of Chemistry, Faculty of Science, University of Adyaman, Adyaman, Turkey
4Department of Biology, Faculty of Science, University of Firat, Elazg, Turkey

Objective: 

Hydrogen Peroxide (H2O2) is a powerful reactive oxygen species and causes oxidative damage the proteins and lipids. The aim of the present study was to evalute the neuroprotective effect of Coenzim Q-10 (Ubiquinone) on H2O2-induced oxidative damage in rats.

Methods: 

Forty male Wistar albino rats were randomly divided into four groups as control, H2O2, Ubiquinone (UB) and H2O2+UB groups. H2O2 (10 mg/every other day) and UB (8 mg/every other day) were intraperitoneally administered for a period of 38 days. At the end, the rats were decapitated and brains were rapidly removed. After homogenization, total lipid and total cholesterol levels were analyzed by spectrophotometer, and fatty acid levels were determined by gas chromatography.

Results: 

In brain tissue, total cholesterol levels were not statistically different from control group (p>0.05), however total lipid levels were decreased in UB group as compared to average results (p>0.05). Also, the ratio of total w-3-fatty acid and total polyunsaturated fatty acid (PUFA) in the UB group increased (p>0.05) compared to control group, but these results were not statistically significant for the brain lipid metabolism.

Conclusions: 

We conclude that Coenzim Q-10 does not seem to have a neuroprotective potential in the rat brain.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC257

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