Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
VITAMIN E REDUCES OXIDATIVE STRESS AND IMPROVES HEMORHEOLOGICAL PARAMETERS IN AGED RATS
Abstract number: PC252
Kkatay1 Vural, Bor Kucukatay1 Melek, Gundogdu1 Gulsah, Erken2 Gulten, Olgun Ozcan1 Tonguç, Demirkaya Miloglu3 Fatma, Kadioglu3 Yucel
1Pamukkale University, Faculty of Medicine, Department of Physiology Knkl, 20020, Denizli/TURKEY
2Balkesir University, Faculty of Medicine, Department of Physiology, 10100 Balkesir/TURKEY
3Ataturk University, Faculty of Pharmacy, Department of Analytical Chemistry, 25240, Erzurum/TURKEY
The harmful effects of aging on blood rheology have been well known. These effects in the aging have been found to be associated with an increase in oxidative stress. The aim of this study was to seek whether treatment of Vitamin E which is a potent antioxidant could improve the age-related hemorheological abnormalities.
For this purpose, male Wistar rats at the age of 3 and 24 months were used and the following parameters were evaluated: Red blood Cell (RBC) deformability and aggregation, plasma viscosity, plasma Vitamin E level, Total Oxidant Status (TOS) and Total Antioxidant Status (TAS).
The results show that aging is associated with a decrease in RBC deformability and increase in RBC aggregation and plasma viscosity. Compared with young group, aged rats had significantly lower TAS and higher level of TOS in plasma. We also found significantly lower plasma Vit E level in aged rats than young rats. Vitamin E administration produced significant increase in RBC deformability and decrease in RBC aggregation in aged group with respect to young and aged control groups. While TOS levels were decreased, an increment in TAS levels was seen in plasma of old rats treated by Vitamin E.
Conclusions:In conclusion, these findings suggest that blood rheology impairs with age and Vitamin E has ameliorating effects on aged-induced hemorheological abnormalities probably by reducing increased oxidative stress in old age. This study was supported by Pamukkale University Research Fund.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC252