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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


MELATONIN PREVENTS ALUMINUM-INDUCED OXIDATIVE DAMAGE IN RAT INTESTINE
Abstract number: PC246

Sarkaya1 Güner, Karabulut Bulan1 Ömür, Arda Pirincci2 Pelin

1Division of General Biology, Department of Biology, Faculty of Science, Istanbul University, Turkey
2Division of Zoology, Department of Biology, Faculty of Science, Istanbul University, Turkey

Objective: 

Aluminum enters into the body from the environment, diet and medications, is extensively used in modern daily life. Aluminum shows toxic effect in various tissues by expose of reactive oxygen species (ROS). Melatonin, produced by the pineal gland, has been shown to be an effective antioxidant and free radical scavenger. In this study, we aimed to investigate the effects of melatonin on intestinal injury induced by aluminum in rats.

Methods: 

Wistar albino rats used in this study were divided into five groups. Group I: control animals, group II: melatonin control animals which were injected with physiological saline and ethanol, group III injected with 10mg/kg melatonin, group IV 5 mg/kg aluminum sulfate injected and, group V 5 mg/kg aluminum sulfate and 10 mg/kg melatonin injected. All groups were injected three times a week for one month. Jejunum samples were prepared for light microscopic examination and were stained with Masson's trichrome. Myeloperoxidase (MPO) as an oxidative stress marker and glutathione (GSH), which is a parameter of antioxidant system, were examined in the intestinal homogenates by ELISA.

Results: 

Administration of aluminum resulted in a common injury in the small intestine by causing degenerative changes. In addition, aluminum exposure promoted oxidative stress with a significant increase myeloperoxidase (MPO) levels and decrease in glutathione (GSH) levels in small intestine. Melatonin administration decreased degenerative changes. Melatonin administration decreased myeloperoxidase (MPO) levels and increased GSH levels biochemically.

Conclusions: 

Our results showed that melatonin has protective effects on aluminum-induced small intestinal injury in rats. Also we suggested that melatonin may be useful as a therapeutic agent in aluminum-induced intestinal disorders.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC246

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