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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


ALTERATIONS IN RED BLOOD CELL RHEOLOGICAL PROPERTIES IN HEALTHY PERSONS LIVING AT LOW AND MID-ALTITUDES
Abstract number: PC232

Aydoan1 Sami, Seda Artis1 Ai[scedil]e, Basaran1 Erdem, Dolu1 Nazan

1University of Erciyes, Medical Faculty, Department of Physiology, 38039, Kayseri, Turkey

Objective: 

After living at high altitude for a long time, the body begins to adapt to the oxygen shortage. The most important adaptation may be an increase in the number of red blood cells (RBC). On the other hand, in microcirculation, blood flow and adequate oxygen delivery to tissue are mainly dependent on RBC rheologic properties. In this study, the changes of hemorheological properties of two groups of healthy people who lived at low (1300 m) and mid (2300 m) altitudes were investigated.

Methods: 

Twenty-six healthy volunteers in each group were studied and hematologic and hemorheologic parameters were measured from blood samples. Hemoglobin (HGB), packed cell volume (PCV), RBCs, MCV, MCH and MCHC were measured by means of an electronic particle counter. Deformability of RBC was measured by Rheodyne SSD Laser Diffractometer. Aggregation measurements were done by Myrenne Aggregometer. RBC osmotic fragility was determined in a series tubes with increasing concentrations of NaCl solution by spectrophotometer and calculated as 50% hemolysis.

Results: 

RBC, HGB and PCV values were higher at mid altitudes than those at low altitudes. However, there were no significant differences in MCV, MCH and MCHC as red cell indices between two groups. In the other hands, as rheological parameters, erythrocyte deformability and osmotic fragility values were lower who lived at mid altitude compared to low altitude, but an increased were observed in RBC aggregation index (M1).

Conclusions: 

We conclude that especially hemorheological changes of red blood cells at different altitudes can be an important signal for high altitude diseases.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC232

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