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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


LONG-TERM EXERCISE TRAINING LOWERED THE DESTRUCTIVE EFFECTS OF THE OXIDANTS IN MUSCLES EXPOSED TO EXHAUSTING EXERCISE
Abstract number: PC229

Taylan Deveden1 Elçin, Goktas2 Güleser, Ozer1 Ci[gbreve]dem, Aral3 Arzu, Erdogan2 Deniz, Pinar1 Lamia

1Department of Physiology, Gazi University, Ankara, Turkey
2Department of Histology,Gazi University, Ankara, Turkey
3Department of Immunology,Gazi University, Ankara, Turkey

Objective: 

In this study we eveluated the muscle damage depend on exhausting exercise and the effects of exhausting exercise on oxidative stress in rats that underwent acute and chronic exercise.

Methods: 

48 male Wistar albino rats were used and long-term (12week/5day/30min) exercise trained (chronic) and untrained (acute) rats were forced to make exhausting exercise, and they were sacrificed; just after exhaustion, 1 day and 3 days following exhaustion. Free oxygen radicals (MDA), that are reported being responsible for muscle damage after exercise, and antioxidants (GSH) as a scavenger of the oxidants were assessed in rats spectrophotometrically and extend of muscle damage were assessed histologically respectively.

Results: 

After exhaustion, there were significantly increase in oxidants and also the signs of destruction in the muscle fibers in both groups. However the findings of muscle damage and oxidant levels were found higher and antioxidant levels lower in acutely running rats in all groups comparing to the chronically exercise-trained rats. Maximum muscle damage and oxidant levels emerged 1 day after exhaustion in both trained and untrained groups that were analyzed. The drop of oxidants and increase in antioxidants and the visualized regeneration process in histological samples appeared more significantly in the third day after exhaustion in the trained animals but not in the acutely run animals.

Conclusions: 

These data showed that degeneration process in the muscles intensified one day after exhaustion in both trained and untrained groups, however regeneration process developed significantly 3 days after exhaustion in chronic groups, but the regeneration signs was not significant in acutely run rats 3 days after exhaustion.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC229

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