Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
THE EFFECTS OF DOCOSAHEXAENOIC ACID SUPPLEMENTATION AND EXERCISE ON GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR I SERUM LEVELS DURING CHRONIC HYPOXIA IN RATS
Abstract number: PC220
Turgut1 Sebahat, Ali Erken2 Haydar, Erken3 Gülten, Ayada1 Ceylan, Genc1 Osman, Turgut1 Günfer
1Department of Physiology, Faculty of Medicine, University of Pamukkale, Denizli, Turkey
2State Hospital of Balkesir, Balkesir, Turkey
3Department of Physiology, Faculty of Medicine, University of Balkesir, Balkesir, Turkey
In this study it was examined the effects of docosahexaenoic acid (DHA) on growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in response to chronic hypoxia and exercise training in hypoxic conditions.
Thirty-five rats were divided into five groups; control group (C), hypoxia group (H), hypoxia-exercise group (HE), hypoxia-docosahexaenoic acid group (HD), hypoxia-exercise- docosahexaenoic acid group (HED). A treadmill exercise was performed as 30 m/min for 20 min/day, five days per week for 28 days at level grade in exercise groups. DHA was given HD and HED groups every day orally (36 mg/kg). The animals except controls were exposured to hypoxia during twenty-eight days.
Serum levels of GH and IGF-I in H group decreased after chronic hypoxia (p<0.001). GH and IGF-I in HD group also decreased compared with C group (p<0.05, p<0.01, respectively). GH in controls did not show significant difference compared with HE and HED groups. Decreased serum level of IGF-I was observed for HED group (p<0.05).
According to findings, we can say that chronic hypoxia exposure decreases serum levels of GH and IGF-I and exercise training have slightly positive effect on GH/IGF-I axis during hypoxia. Also DHA supplementation slightly increases GH and IGF-I serum levels in hypoxic conditions. But this effect on GH/IGF-I axis during hypoxia is not strong compared with exercise. That's why we concluded that exercise and/or DHA supplementation doesn't have additional positive effect on these hormones in hypoxic conditions.
This study was supported by Pamukkale University Research Fund.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC220