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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey
THE EFFECT OF KISSPEPTIN ON GHRELIN AND BODY WEIGHT IN YOUNG MALE RATS
Abstract number: PC186
Aydin1 Mehmet, Sefil1 Fatih, Yildiz2 Sedat, Yilmaz3 Bayram
1Department of Physiology, Medical Faculty, Mustafa Kemal University
2Department of Physiology, Medical Faculty, Inonu University
3Department of Physiology, Medical Faculty, Yeditepe University
Objective:
Kisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions. We have investigated direct and indirect effects of kisspeptin on the serum ghrelin and follicle-Stimulating Hormone (FSH) levels, and body and testicular weight in young male rats.
Methods:
Twenty-four male Wistar rats (6 weeks of age) were divided into four groups (n=6/group). First group served as control and received saline. Kisspeptin-10 was administered to the animals in the second group (20nmol/rat/day) for a period of seven days. Rats were given only one dose gosereline (0.9mg/rat), a GnRH agonist in the third group. The last group received kisspeptin-10 with gosereline. Serum ghrelin and FSH levels were determined by RIA and ELISA, respectively.
Results:
Serum ghrelin levels were increased in the gosereline groups in comparison with the other three groups (p<0.01). Serum FSH levels were lower in the groups treated with gosereline group than in both control and kisspeptin (p<0.01 and p<0.05). Kisspeptin-alone application, on the fourth day, reduced body weight. Testicular weights were lower in the groups treated with gosereline (p<0.01). Positive correlations were found between ghrelin levels and body weight, between testicular weight and FSH levels (p<0.01).
Conclusions:
In conclusion, our findings suggest that kisspeptin may directly have a suppressive effect on ghrelin and body weight. Kisspeptin, this way, may have a modulatory effect on energy balance.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC186