Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
THE EFFECTS OF MELATONIN ON THE INCREASED HSP70 IMMUNOREACTION IN THE LIVER INDUCED BY EXPERIMENTAL CCL4 TOXICITY
Abstract number: PC185
Karaca1 Omur, Pekmez2 H[inodot]d[inodot]r, Abdulgani Kus3 Murat, Akpolat4 Nusret, Ogeturk2 Murat, Kus1 Ilter
1Department of Anatomy, Balikesir University, Balikesir, Turkey
2Department of Anatomy, Firat University, Elazig, Turkey
3Health college, Mehmet Akif University, Burdur, Turkey
4Department of Anatomy, Inn University, Malatya, Turkey
Carbon tetrachloride (CCl4) is a volatile organic chemical, which causes tissue damage, especially to the liver and kidney. The potential for protective effects of melatonin on carbon tetrachloride-induced acute liver injury in rats was investigated in this study.
Twenty-four male Wistar-Albino rats were randomly divided into three equal groups: Control, CCl4 and CCl4 plus melatonin (CCl4+Melatonin). Rats in CCl4 group were injected subcutaneously with CCl4 0.5 ml/kg in olive oil while rats in CCl4+Melatonin group were injected subcutaneously with CCl4 (0.5 ml/kg) plus melatonin (25 mg/kg) every other day for one month. Control rats were injected olive oil. Liver tissues were stained with heat shock protein 70 (Hsp70) immunohistochemically performed.
A dense staining indicating Hsp70 immunoreaction was observed in the liver depending on the toxicity of CCl4. The liver tissue sections of rats injected with melatonin and CCl4, the HSP70 staining was detected minimal.
Results of the present study have shown that CCl4 induced tissue damage in the liver is prevented by melatonin administration.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC185