Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
KISSPEPTIN HAS DIFFERENTIAL EFFECTS ON PLASMA NEUROPEPTIDE Y AND PEPTIDE YY CONCENTRATIONS IN YOUNG MALE RATS
Abstract number: PC180
Canpolat1 Sinan, Alver2 Ahmet, Mentese2 Ahmet, Saral1 Sinan
1Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
2Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
Neuropeptide Y (NPY) and peptid YY (PYY) are important neuromediators related to feeding behaviour in mammals. New peptide hormone kisspeptin has an essential role for the onset of puberty and gonadal function by stimulating the secretion of gonadotropin-releasing hormone. There are very limited studies regarding effect of kisspeptin on blood NPY and PYY concentrations. We have therefore investigated effects of kisspeptin on plasma levels of NPY and PYY in relation with feeding behaviour.
Young male Sprague-Dawley (7 weeks old) rats were used in this study. Kisspeptin (20nmol/kg/day) was intraperitoneally administered for 12 days (n=8). Control animals received vehicle alone (n=8). Animals were decapitated one hour later after the last kisspeptin administration on the 12th day of experiments and blood samples were collected. Plasma concentrations of NPY and PYY were analysed by ELISA. Mann-Whitney U Test was used for statistical evaluations.
Kisspeptin treatment increased plasma NPY level (P<0.01). Plasma PYY concentration was decreased in kisspeptin treated group compared to control (p<0.05).
Results from this study demonstrate for the first time that exogenous kisspeptin administration decrease plasma PYY level. The present findings indicate that kisspeptin may have an orexigenic effect in the post-pubertal young male rat by increasing NPY and decreasing PYY levels.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC180