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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


THE GROWTH HORMONE RECEPTOR POLYMORPHISM IN PATIENTS WITH ACROMEGALY: RELATIONSHIP TO BMI AND GLUCOSE METABOLISM
Abstract number: PC169

Turgut1 Sebahat, Akin2 Fulya, Ayada1 Ceylan, Topsakal2 [Scedil]enay, Yerlikaya2 Emrah, Turgut1 Günfer

1Department of Physiology,Faculty of Medicine, University of Pamukkale, Denizli, Turkey
2Division of Endocrinology,Department of Internal Medicine, Faculty of Medicine, University of Pamukkale,Denizli, Turkey

Objective: 

The aim of this study was to investigate the association between the frequencies of Growth Hormone receptor (d3GHR) gene polymorphisms and some clinical parameters of acromegalic patients.

Methods: 

A total of 35 acromegalic patients were enrolled to the study. The d3GHR polymorphism was identified by using polymerase chain reaction from peripheral blood samples. The levels of systolic and diastolic blood pressure, BMI, fasting plasma glucose (FPG), Fasting insulin, HOMA-IR, IGF-I, GH, IGFBP3, triglyceride, HDL and LDL cholesterol concentrations were evaluated.

Results: 

The frequencies of d3GHR genotypes were found as follows; 5 (14.3%) subjects had d3/d3, 11 (31.4%) had d3/fl and 19 (54.3%) had fl/fl in patients. The prevalence of the d3 and fl alleles was %30 and %70, respectively. Systolic blood pressure, fasting insulin and HOMA-IR was found significantly increased in homozygote d3GHR genotype group compared to d3/fl subjects (p<0.05). In addition, BMI was observed significantly different among three genotypes (p=0.007) and in the subjects with d3/d3 genotype, BMI was found significantly higher than d3/fl and fl/fl genotypes groups. As well as, no significant difference was found between the d3 and fl alleles group in terms of the clinical parameters except for BMI (p=0.002).

Conclusions: 

It can be said that the d3GHR gene polymorphism may affect BMI, systolic blood pressure and insulin regulation. At the same time, we can say homozygote d3GHR genotype and d3 allele carriers may have more risk than other genotypes for high BMI.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC169

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