Objective: 

The aim of the present study was to evaluate the responses to Auditory Oddball Paradigm in reference to hand preference.

Methods: 

Twenty healthy volunteers (10 right-handed, 10 left-handed) participated in this study. Brain electrical activity (EEG) recorded by using WinEEG program (MITSAR) from 19 different locations. Volunteers were instructed to press a button every time when they hear the low frequency sound (target stimulus) and not to press button when they hear high frequency sound (standard stimulus). In average 330 stimuli were applied with percent 20 target stimulus (I.U. Ethics Commision File No: 2009/2648-43). Repeated measured ANOVA (SSPSS-PC 16.0) test is used for the statistical analysis.

Results: 

The P300 latency of left-handed volunteers had longer than in right-handed volunteers [F(1,9)=5,528, p=0.043] by Auditory Oddball Paradigm, but there had no significant difference between left- and right-handed volunteers in amplitude of P300 response [F(1,9)=0.037, p=0.852]. There had no significant difference at the amplitude of P300 responses between right and left hemisphere [F(1,9)=0.954, p=0.354] and also at the values of latency [F(1,9)=0.195, p=0.669] of right-handed volunteers. And also there had no significant difference at the amplitudes [F(1,9)=0.026, p=0.875] or latencies [F(1,9)= 0.256, p=0.625] of the P300 responses between hemispheres of left-handed volunteers.

Conclusions: 

The present study demonstrates the hemispheric properties of the cognitive functions between volunteers with right-handed and left-handed. This work was supported by Scientific Research Projects Coordination Unit of Istanbul University (Project # 4965).