Objective: 

In our study, the role of olivocochlear system prevention of cochlear damage due to noise, using antagonist of dopamin (haloperidol) were examined electrophysiologically.

Methods: 

As a result of distortion product otoacoustic emission (DPOAE) measuring and auditory brainstem responses (ABR), 18 ears of 9 guinea pigs with detected normal hearing threshold and emission, have been taken into the scope of this study, and they were randomly divided into three groups. The first group of these three groups was planned as the experiment group, the second one as the working group, and the third group have been planned as the control group. The guinea pigs of the experiment group were administered only haloperidol (0.5 mg/kg), the other group was treated with haloperidol (0.5 mg/kg) and acoustic trauma (110 dB, 10 minutes, large band noise). The guinea pigs in the control group were exposed to acoustic trauma (110 dB, 10 minutes, large band noise) and received physiological saline. DPOAE and ABR measurements repeated after administration at the time of 30th, 60th, 90th and 120th minutes.

Results: 

No statistically significant difference was observed when DPOAE (Signal/Noise ratio), ABR tresholds of hearing assessed in all groups prior to medicine and noise administration. In the experimental group, after administration there was no significant difference in DPOAE and ABR measurements.

Conclusions: 

In conclusion, a protective effect on the functioning of the olivo-cochlear system in noise induced cochlear damage is temporarily affected by the use of haloperidol.