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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey
MEDICAL OZONE PREVENTS THE HARMFUL EFFECTS OF CADMIUM ON NEUROLOGICAL FUNCTIONS IN RATS
Abstract number: PC133
Erken1 Haydar Ali, Erken2 Gülten, Karaca3 Ömür, Bahar Sunay4 Fatma, Genc5 Osman, Seyrek6 Kamil, Aksit7 Hasan, Kus3 Ilter
1Balikesir State Hospital, Balikesir
2Balikesir University, Faculty of Medicine, Department of Physiology, Balikesir
3Balikesir University, Faculty of Medicine, Department of Anatomy, Balikesir
4Balikesir University, Faculty of Medicine, Department of Histology and Embryology, Balikesir
5Dumlupinar University, Faculty of Medicine, Department of Physiology, Kutahya
6Balikesir University, Faculty of Medicine, Department of Biochemistry, Balikesir
7Balikesir University, Faculty of Veterinary Medicine, Department of Biochemistry, Balikesir
Objective:
It is well known that cadmium has harmful effect on neurological functions. The aim of this study was to investigate the protective effects of ozone on rats exposed to cadmium.
Methods:
A total of 28 Sprague Dawley male rats, were divided into 4 groups, each consisting 7 rats: Control (C), Cadmium (Cd), Cadmium+Oxygen (Cd+Ox), Cadmium+Ozone (Cd+Oz). Cadmium was given to all groups except the control for fifteen day (0.9mg/kg/day Cd, i.p, dissolved within 1ml SF). % 97 Oxygen was given to Cd+Ox group (4.5 ml/day, i.p.). Ozone was given to Cd+Oz group (1.1 mg/kg/day Ozone, i.p., 4.5 ml). At the end of the experimental period, EEG recordings in anesthetized rats were collected. Sciatic nerves of rats were removed and nerve conduction velocity (NCV) was measured. One Way ANOVA and Post Hoc Tukey tests were used for the differences between groups, p values <0.05 were accepted as statistically significant.
Results:
Delta activity was significantly increased in Cd group when compared to control; but the theta and alpha activities of Cd group were significantly decreased when compared to control. While delta activity was significantly decreased in Cd+Ox and Cd+Oz groups when compared to Cd group, theta and alpha activities of Cd+Ox and Cd+Oz groups were increased compared to Cd group. NCV values of Cd group were decreased when compared to C group; but NCV values were significantly increased in Cd+Oz group when compared to Cd group.
Conclusions:
Our results demonstrated that medical ozone reduced the harmful effects of cadmium exposure on neurological functions.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC133