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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey
DOES OZONE AFFECT BRAIN FUNCTIONS IN DIABETIC RATS?
Abstract number: PC132
Gen1 Osman, Erken2 Gülten, Ayada1 Ceylan, Ali Erken3 Haydar, Demirkaya1 Gül[scedil]ah, Dogan4 Hasan
1Department of Physiology, Pamukkale University, Denizli, Turkey
2Department of Physiology, Balkesir University, Balkesir, Turkey
3Balkesir State Hospital, Balkesir, Turkey
4Ozone Treatment Center, Denizli, Turkey
Objective:
The aim of this study was to compare the effects of insulin and medical ozone therapy on total EEG activity and EEG frequency bands in diabetic rats.
Methods:
Thirty female rats were divided into 5 groups, each consisting 6 rats: Control (K), diabetes (D), ozone (O), diabetes + insulin (DI), diabetes + ozone (DO). Diabetes was induced by a single ip injection of Streptozotocin. Ozone was applied by ip injection (1.1 mg/kg/d) to O and DO groups for 15 days. Insulin was administered as ip injection. The rats were anesthetized and the EEG recordings were collected. One Way ANOVA and Post Hoc Tukey tests were used, P values <0.05 were accepted as statistically significant.
Results:
Total EEG activity of D was increased compared to group K. While total activity of the DO group were similar to control values, total EEG activity of O group was decreased compared to group K. But, these alterations were not statistically significant. Total EEG activity of K, D, O and DO groups were increased compared to group DI. The frequency analysis did not reveal any significant alterations among the groups.
Conclusions:
Diabetes and medical ozone therapy caused opposite effects on the EEG activity. These findings suggest that medical ozone treatment may decrease the negative effects of diabetes on brain function.
This study was supported by Pamukkale University Research Fund.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC132