Objective: 

The objective of this study was to determine the effect of magnetic field (MF) in right hemisphere, left hemisphere, and cerebellum blood-brain barrier (BBB) in febrile convulsive (FC) rats.

Methods: 

Totally, 36 male and 21 days-old Wistar-Albino rats were used. Rats were divided into six groups: sham; exposed to no MF, FC; febrile convulsion, MF; exposed to MF, FCMF; exposed to MF after FC, MFFC; exposed to MF before FC, MFFCMF; exposed to MF before and after FC. In all groups, the BBB was investigated in right hemisphere, left hemisphere, and cerebellum. FC was created by application of hyperthermic water. Magnitude of 5.0 mT with 50 Hz frequency modulation MF was applied.

Results: 

When the evans-blue (EB) values, obtained from different regions in FC, MF, FCMF, MFFC, MFFCMF were compared; cerebellum values were significantly higher than both hemispheres (p<0.05). The cerebellum, right and left hemispheres' EB values of MFFCMF group were the highest (p<0.05).

Conclusions: 

In FC, the application of MF had more influence on cerebellum comparing to both hemispheres in terms of BBB. This result suggested that cerebellum was more sensitive to MF in terms of BBB. Only MF and FC application had deteriorative effect on BBB of rats. Additionally, in FC rats BBB was more deteriorated when MF was applied. It was shown that the application of MF after and before FC caused no differences in terms of BBB. However, BBB had more deterioration by the application of MF on FC rats both after and before seizures. It was seen that in FC exposure to MF in longer periods affected BBB more.