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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


AN INTERACTION BETWEEN GINKGO BILOBA AND ACUTE STRESS AND CORTICOSTERONE ON FEAR MEMORY RETRIEVAL AND EXTINCTION IN MICE
Abstract number: PC109

Pour1 Ali Rashidy, Ali Vafaei1 Abbas, Dehbashi1 Fatemeh, Alizadeh1 Neda

1Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran

Objective: 

Acute stress or glucocorticoids modulate various phases of learning and memory.

Methods: 

In this study, we tested preventive effects of a natural medicine the extract of Ginkgo Biloba (EGB 761) on acute stress and corticosterone-induced impairment of fear memory retrieval and extinction.

Results: 

Our findings indicate that acute stress or corticosterone impaired and facilitated fear memory retrieval and extinction in an inhibitory avoidance task, respectively. EGB 761 suppressed the effect of corticosterone, but not acute stress on retrieval and extinction of fear memory.

Conclusions: 

We conclude that, in mice, administration of EGB 761 prevents corticosterone-induced impairment and enhancement of fear memory retrieval and extinction.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC109

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