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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


THE EFFECTS OF NMDA RECEPTORS BLOCKADE AND ENVIRONMENTAL ENRICHMENT DURING DIFFERENT CRITICAL DEVELOPMENTAL WINDOWS OF THE NERVOUS SYSTEM ON THE EMOTIONAL AND COGNITIVE FUNCTION AT ADULT AGE IN THE BALB/C MICE
Abstract number: PC108

Akllolu1 Kübra, Babar Melik2 Emine, Melik2 Enver, Kocahan3 Sayad

1Division of Neurophysiology, Department of Physiology, Medical Faculty, ukurova University, Adana, Turkey
2Retired faculty member of ukurova niversity
3Health School, Adiyaman University, Adiyaman, Turkey

Objective: 

In our study, we evaluated in the situation of NMDA receptor hypoactivity during critical developmental period, the effects of environmental enrichment on locomotor activity, emotional and cognitive functions of the brain at adult age.

Methods: 

For this aim, three "developmental windows", between 5–10 postnatal days as first window, 15–20 postnatal days as second window and 25–30 postnatal days as third window were selected as a model. NMDA receptor hipofunction was performed during these devepomental windows by using MK-801 (for 5 days 0.25 mg / kg twice a day, intraperitoneal). In Balb/c mice treated with MK-801 and reared in physical standart and enriched environmental conditions, emotional behaviors were assessed by using open field, elevated plus maze tests, and cognitive functions were assessed in the Morris water maze.

Results: 

In the first development window (between 5–10 postnatal days), enriched environmental condition did not restore deteriorating effects of MK-801 in locomotor activity (p<0.001), emotional (p<0.01) and cognitive functions (p<0.01). In the second developmental window (between 15–20 postnatal day), MK-801 did not affect fear responses to open field and height, enriched environmental condition (p<0.05) restored MK-801-induced decreases in risk assessment behavior (p<0.01), spatial exploration and impairment in cognitive functions (p<0.05). In the third developmental window (between 25–30 postnatal days), enriched environmental condition (p<0.05) restored MK-801-induced decrease in risk assessment behavior (p<0.05), but not cognitive functions.

Conclusions: 

Physical environmental enrichment can restore disturbances in emotional and cognitive functions dependent on the NMDA receptor hypofunction only during second developmental window. Practically, the physical environmental enrichment could restore NMDA receptor system impairment at early childhood period.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC108

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