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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


AN UNINTENDED DIETARY CONSTITUENT -ACRYLAMIDE- EXERTS ANTICONVULSIVE EFFECT IN MICE
Abstract number: PC101

Arhan1 Okan, Dikmenoglu1 Neslihan H.

1Hacettepe University, Faculty of Medicine, Department of Physiology

Objective: 

Epilepsy is a common neurological disorder, in which diet can be important in prevention or induction of convulsions. Acrylamide is an unintended dietary constituent formed by reaction of carbohydrates and proteins during food processing at high temperatures. Since acrylamide is neurotoxic, we aimed to evaluate the pro/anticonvulsive effect of acrylamide in mice which can be further extrapolated to food intake of epileptic patients.

Methods: 

Male Swiss-albino mice, weighing 30–35 g were divided into 5 groups. Control group received saline. Acrylamide groups were divided according to dose (10 and 50 mg/kg) and time of PTZ injection (½ and 4 hours after acrylamide injection). The drugs were dissolved in saline and were administered intraperitoneally in a volume of 10 ml/kg of body weight. Changes in time interval before the initiation of the first epileptic activity, time required for the generalized convulsions and the duration of the convulsions were accepted as measures of pro/anticonvulsive effect. Kruskal-Wallis test was used for statistical analysis

Results: 

In acrylamide groups, period before the initiation of epileptic activity was prolonged; 49.0 (½ hour-10 mg/kg), 49.9 (½ hour-50 mg/kg), 56.51 (4 hour-10 mg/kg) and 61.17 percent (4 hour-50 mg/kg). Similarly time required for the generalized tonic-clonic convulsions were found to be increased in all of the acrylamide groups. Percent prolongation for acrylamide groups for this parameter were; 7.5 (½ hour-10 mg/kg), 29.3 (½ hour-50 mg/kg), 29.6 (4 hour-10 mg/kg) and 33.4 percent (4 hour-50 mg/kg).

Conclusions: 

The outcome of this preliminary study suggests that acrylamide exerts an anticonvulsive activity in mice, but it was not shown statistically.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC101

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