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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


THE EFFECT OF CO-ADMINISTRATION OF THE NMDA BLOCKER WITH AGONIST AND ANTAGONIST OF CB1-RECEPTOR ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS
Abstract number: PC094

Cakl1 Duygu, Yildirim2 Mehmet, Ayyildiz3 Mustafa, Agar3 Erdal

1Departmen of Physiology, Gaziosmanpaa University, Tokat, Turkey
2Departmen of Physiology, Karadeniz Technical University, Trabzon, Turkey
3Departmen of Physiology, Ondokuz Mays University, Samsun, Turkey

Objective: 

Memantine is an uncompetetive NMDA receptor antagonist, that have potentially wide applications including epilepsy. On the other hand, cannabinoid system plays a key role in regulating seizure activity in brain. In this study we examined the interaction between memantine and cannabinoid system on penicillin induced epileptiform activity.

Methods: 

Rats were anesthetized with urethane (1.25 g/kg, i.p) and placed in stereotaxic frame. Left cerebral cortex was exposed by craniotomy. The epileptic focus was produced by 500 units penicillin G injection. Combinations of Memantine, AM251 and ACEA were used to examine their effects on epileptiform activity. The electrocortigography (ECoG) activity was monitored on a four-channel recorder.

Results: 

Memantine, at doses of 2.5 and 5mg kg, significantly decreased the epileptiform activity. The most effective dose was 5 mg/kg. AM-251 caused a significant increase in epileptiform activity. It also caused development of status epilepticus-like activity. ACEA significantly decreased the epileptiform activity.

AM-251 (0.25 mg, i.c.v) did not influence anti-epileptiform effect of memantine. The best and earlier anti epileptiform effect appeared in the presence of memantine+ACEA.

Conclusions: 

Memantine presented bell-shaped dose-effect relationship in this study. An additional anti-epileptiform effect was seen in the presence of Memantine + ACEA, which was blocked by AM-251. The proconvulsant effect of AM-251 on penicillin-induced epileptiform activity disappeared in the presence of memantine + AM-251, suggesting an interaction between cannabinoid system and NMDA receptors.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC094

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