Objective: 

Damage of the vestibular apparatus following the traumatic brain injury is one of the common brain injuries, which in consequence leads to partial or even total disability. Neurodegeneration of the central and peripheral nervous system is one of the major sociomedical problems.The aim of this work to study of electrophysiological and histochemical features of lateral vestibular nucleus (LVN) and vestibular compensation by mean of NOX venom.

Methods: 

Experiments were carried out on adult; mail Albino rats (230 ±30g). In the first stage animals were randomly categorized into three groups (normal, unilateral labyrenthectomy(UL) and UL with administration of NOX (10% LD50, im three next days after UL). The histochemical properties of LVN neurons were tested by means of recording the activity of Ca²⁺- dependent acidic phosphates. For electrophysiological patterns of LVN neurons were evoked by bilateral stimulation of Paraventricular and supra optic nuclei with high frequency stimulus.

Results: 

The findings of this study were compared with those of normal group. In histochemical results of UL groups, it was shown that neuron leads to neurodegenerative pattern, whereas in the case of NOX administration the recovery of neurons was found. The electrophysiological pattern of LVN neurons demonstrated that after UL there is asymmetric between ipsi and contra lateral sides. But in NOX group was the same as norm group.

Conclusions: 

The findings of this study indicate that following vestibular damage the snake venom probably leads to the recovery of Deiters' neurons and also enhanced the vestibular compensation during recovery.