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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


TRASPLANTATION OF ENCAPSULATED ASTROLGIAL GRAFTS AMELIORATE LESION-INDUCED MOTOR DEFICITS IN ADULT RATS
Abstract number: PC077

Heredia1 Margarita, Antonio1 Fuente, Jose Maria1 Criado, Diaz Lydia1 Jiménez, Javier1 Yajeya, Mauricio1 Nava, Adelaida1 Riolobos

1Department of Physiology and Pharmacology. INCyL. Salamanca University, Salamanca, Spain

Objective: 

We have previously shown the functional recovery of skilled forelimb use in rats after grafting of the frontal cortex lesion with cortical or amygdalar fetal tissue when rats were obliged to use the impaired limb. Here, we aimed to explore the effects of astrocyte grafts on the motor impairments caused by frontal cortex lesion in adult rats.

Methods: 

Animals were conditioned in a paw-reaching-for-food task and the preferred paw was determined. Animals were anaesthetised in all stages of subsequent procedures (Equithesin, 20 mg/kg i.p.). Experimental animals were lesioned by aspiration in the motor cortex contralateral to the preferred paw. Astrocytes encapsulated in alginate spheres were implanted in the lesion cavity in one group of rats; fetal cortical tissue in a second group; and empty alginate spheres in a third group. The three groups were compared with a sham-operated control group.

Results: 

Three months later, both rats with encapsulated astrocyte or fetal cortical transplants ameliorated the motor deficit caused by the lesion. Rats with empty alginate sphere implants showed no improvement. Animals with alginate sphere grafts showed an increase in the lesion size.

Conclusions: 

In summary, our findings show that transplants of astrocytes encapsulated in alginate spheres induce a long-term improvement of motor deficits caused by the lesion, however they produce side effects on the host. This work was supported by the MAPFRE Foundation. The authors thank to Noelia González and Javier Blanco for their excellent technical assistance.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC077

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