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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


ALTERATIONS OF CENTRAL HYPERCAPNIC RESPIRATORY RESPONSE INDUCED BY ACUTE CENTRAL ADMINISTRATION OF SEROTONIN RE-UPTAKE INHIBITOR, FLUOXETINE
Abstract number: PC074

Sahin1 Gülderen, Guner1 Ibrahim, Yelmen1 Nermin, Yaman1 Onur, Mengi1 Murat, Simsek1 Gonul, Sipahi2 Sevtap

1Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Turkey
2Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Turkey

Objective: 

The role of increased central concentration of serotonin(5-HT) by inhibiting its re-uptake via fluoxetine on the central hypercapnic ventilatory response (CHVR) is complex and little is known. We aimed to research the effect of acute intracerebroventricular (ICV) injection of fluoxetine on CHVR in the absence of peripheral chemoreceptor impulses. In addition we determined the effect of ketanserin (5-HT2 receptors antagonist) on these responses.

Methods: 

Anesthetized rabbits were divided as Fluoxetine and Ketanserin groups. For ICV administration of fluoxetine and ketanserin, a cannula was placed in the left lateral ventricle by the stereotaxic method. Respiratory frequency (fR), tidal volume (VT) and ventilation minute volume (VE) were recorded in both groups.

Results: 

ICV fluoxetine (10.12 mMol/kg) injection during normoxia caused increases in VT and VE (P < 0.01) in the fluoxetine group. When the animals were switched to hypercapnia f/min, VT and VE increased significantly. The increases in percentage values in VT and VE in Fluoxetine + Hypercapnia phase were higher than those during hypercapnia alone (P < 0.01, P < 0.05). There was an increase in CO2 sensitivity Index in the Fluoxetine +Hypercapnia phase (P < 0.01). On blocking of 5-HT2 receptors by ketanserin (0.25 mMol/kg), the degree of increases in VT and VE in the Ketanserin + Hypercapnia phase were lower than those during hypercapnia alone (P < 0.01, P < 0.001). CO2 sensitivity Index also decreased (P <0.01).

Conclusions: 

We concluded that acute central fluoxetine increases normoxic ventilation and also augments the stimulatory effect of hypercapnia on respiratory neuronal network by 5-HT2 receptors in the absence of peripheral chemoreceptor impulses.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC074

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