Objective: 

The aim of the present study was to evaluate differences in serum levels of neopterin, adhesion molecules and myeloperoxidase (MPO) between coronary artery disease and metabolic syndrome (CAD-MetS) patients with stable and unstable angina pectoris (SAP, UAP), and to clarify relationships between neopterin and other biomarkers.

Methods: 

The study included 60 patients with CAD-MetS who were classified into two groups, 30 patients with SAP and 30 patients USP. 20 healthy subjects were selected as controls (C). Serum soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), sE-selectin and MPO levels were measured by Luminex xMAP technology, but serum neopterin concentrations were measured by radioimmunoassay.

Results: 

Serum levels of neopterin, MPO, sVCAM-1, sICAM-1, and sE-selectin were significantly higher in patients with UAP in comparison with the group of healthy controls (p<0.05). Patients with SAP also had higher levels of these biomarkers than healthy controls (p<0.05), except for sE-selectin. The biomarkers did not differ between the two patient groups, except for MPO, which was significantly higher in the USP group (p<0.05). Neopterin was significantly correlated only with sVCAM-1 (p<0.05).

Conclusions: 

CAD-Met patients with SAP have more apparent elevations of serum sICAM-1 and sVCAM-1 levels, simultaneously with higher MPO and neopterin concentrations than healthy subjects, but UAP is also associated with more substantial changes in MPO and significantly increased sE-selectin levels. Neopterin has a close correlation only with sVCAM-1.

Acknowledgement: This study was supported in part by European Economic Area grant EEZ08AP-5/2 and grant No. 2010.10-4/VPP-4/5 of the framework of the Latvian National Program.