Meeting details menu

Meeting Authors
Meeting Abstracts
Keynote lectures
Oral communications
Poster presentations
Special symposia
Other

Acta Physiologica Congress

Back

Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


HYPOXIC ADAPTATION IS ASSOCIATED WITH THE MUSCLE THIOREDOXIN AND HEAT SHOCK PROTEIN RESPONSES
Abstract number: PC039

Gney1 [Scedil]evin, Korkmaz1 Ayhan, Sebnem Ilhan2 Ay[scedil]e, Atalay3 Mustafa, Dincer1 Sibel

1Gazi University, Faculty of Medicine Department of Physiology, Ankara, Turkey
2Bakent University, Faculty of Medicine, Department of Physiology, Ankara, Turkey
3University of Eastern Finland, insttute of Biomedicine, Department of Physiology, Kuopio, Finland

Objective:In the present study we aimed to investigate the levels of HSPs, a major intracellular defense system for protein homeostasis, and antioxidant redox regulator thioredoxin in soleus muscle after the exhaustive exercise in the conditions of hypoxic adaptation.

Methods: 

Eight-week-old Wistar Albino male rats were divided in normoxia (n=6) and hypoxia (n=7) groups. Rats in the hypoxia group were exposed to 10% hypoxia in a hypoxic chamber for 2 days. After the hypoxic exposure, all animals were subjected to exhaustive exercise on a treadmill and running time to exhaustion was recorded as exhaustion time. Upon exhaustion, they were sacrificed by cardiac puncture, and soleus muscle samples were collected for further analyses. Levels of HSP 60, HSP70, HSP90 and thioredoxin were measured by western blotting.

Results: 

There were no statistically significant changes for the measured parameters in hypoxia group, when they compared with their normoxic controls. However there was a positive correlation between Trx and HSP70 in both normoxia and hypoxia groups. There was also a positive correlation between exhaustion time and thioredoxin, HSP70, HSP90 in hypoxia group. Increase in HSP 70 and HSP 90 levels are positively correlated in hypoxia group too.

Conclusions: 

Correlations among the measured parameters suggest that hypoxic adaptation might increase the exercise performance and contribute to protection against exercise induced muscle damage by activating HSPs and thioredoxin in the muscle.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :PC039

Our site uses cookies to improve your experience.You can find out more about our use of cookies in our standard cookie policy, including instructions on how to reject and delete cookies if you wish to do so.

By continuing to browse this site you agree to us using cookies as described in our standard cookie policy .

CLOSE