Objective: 

The present study was conducted to assess 3435C>T Multidrug Resistance 1 gene polymorphism and the efficacy of high dose methylprednisolone(HDMP) in childhood acute Idiopathic thrombocytopenic purpura.

Methods: 

A total of 31 childhood acute Idiopathic thrombocytopenic purpura (17 females, 14 males) between the ages of 2 years to 16 years were included in the study. High-dose methyl prednisolone was was given at a dose of 30 mg/kg/day for 3 days and 20 mg/kg/ day for 4 days, consecutively and intravenously. Fragments obtained were 238 bp to T/T genotype, 172 bp and 60 bp fragments to the C/C genotype, and 238 pb, 170 bp and 60 bp to the C/T genotype.

Results: 

The distribution of CC, CT and TT genotypes were 19%, 61.3.%,19.4%, respectively.There was no significant difference in genotype and allele distribution between the patients with ITP and the controls (x2 = 0,84 p=0.65, x2 = 0,2 p=0.63, respectively. There was no significance in age, gender, pre-treatment and post-treatment platelet count between CC, CT and TT genotypes of MDR gene. After 1 year follow-up, becoming chronic course rates in CC, CT and TT genotypes were 33,3%, 47,3%, 50%, respectively.The distribution of genotype, age and gender weren't significant risk factors in logistic regression analysis of becoming chronicity. The odd ratio in individuals with CC/CT genotype was 1.25 (p>0.5).

Conclusions: 

In our study, there was no difference in HDMP treatment response between MDR1 gene genotypes. We have a small group of patients, our data should be considered preliminary, awaiting further confirmatory studies.