Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
IS GLU27 ALLELE A DETERMINANT OF ASSOCIATION AMONG BONE MINERAL DENSITY AND FAT MASS, WEIGHT AND BODY FAT?
Abstract number: OC25
Da1 Figen, Erdal2 Mehmet Emin, Cimen3 Özlem Bölgen, Edgunlu4 Tuba Gökdo[gbreve]an, Altun3 Resa, Beydagi1 Hüseyin
1Department of Physiology, Medical Faculty, Mersin University, Mersin, Turkey
2Department of Medical Biology and Genetics, Medical Faculty, Mersin University, Mersin, Turkey
3Department of Physical Medicine and Rehabilitation, Medical Faculty, Mersin University, Mersin, Turkey
4Healthy Science School, Mula University, Mula, Turkey
Bone mineral density (BMD) is the most crucial determinant of bone strength. While some studies suggested that lean body mass (LBM), but not fat mass (FM), was related with BMD; other studies have demonstrated that FM, but not LBM, is an important determinant of BMD. Individual genetic specifications may be the reason of these controversial findings. The polymorphism on codon 27 was more frequent in overweight people and Glu27 allele was associated with weight gain, fat mass and obesity. The purpose of this study was to address the relationship between the anthropometric parameters and lumbar BMD in postmenopausal women who carry Glu27 allele.
Forty-four postmenopausal women (55.45±5.55 years) participated in our study. BMD was measured for anteroposterior lumbar spine (L1-L4) by DXA. FM, body fat % (%BF), LBM and weight were determined. The ADRB2 polymorphism (Gln27Glu) was identified by PCR-RFLP.
There were no significant differences between Glu27 allele carriers and non-carriers in mean values of FM, %BF, LBM and weight. While positive significant correlations were found between lumbar BMD and FM (r= 0.43), % BF (r=0.41) and weight (r=0.40) in Glu27 allele carriers, there was no significant relationship in Glu27 non-carriers. Yet, the relationship between lumbar BMD and LBM was significant neither in Glu27 allele carriers nor in non-carriers.
Our results suggest that the presence of the Glu27 allele may be the determinant factor of the association among BMD and FM, and weight. It can be speculated that FM, %BF and weight may not have protective effects on every individual, as claimed, but may be protective only for individuals who carry Glu27 allele.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :OC25