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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


ALTITUDE TRAINING INDUCED ALTERATIONS IN ERYTHROCYTE RHEOLOGICAL PROPERTIES AND OXIDATIVE STRESS
Abstract number: OC18

Kkatay1 Melek Bor, Colak2 R[inodot]dvan, Erken3 Gülten, Toprak1 Emine K[inodot]l[inodot]c, Kucukatay1 Vural

1Department of Physiology, Pamukkale University, School of Medicine, Denizli, TURKEY
2skp Primary School Baclar, Istanbul, TURKEY
3Department of Physiology, Balkesir University, School of Medicine, Balkesir, TURKEY

Objective: 

Altitude training is frequently used by athletes to improve sea-level performance. However, the objective benefits of altitude training are controversial. This study aimed to investigate the possible alterations in hemorheological parameters and oxidative stress in response to altitude training.

Methods: 

37 Sprague Dawley male rats, were divided into 6 groups: live low-train low (LLTL), live high–train high (LHTH), live high-train low (LHTL) and their controls live high and low (LHALC), live high (LHC), live low (LLC). LHC and LHTH groups were exposed to hypoxia (15% O2) for 4 weeks. LHALC and LHTL were exposed to 12 hours hypoxia / normoxia per day, 4 weeks. Hypoxia was maintained by hypoxic tent. The training protocol corresponded to 60–70% of maximal exercise capacity. Rats of training groups ran on treadmill for 20–30 min a day, 4 days per week, 4 weeks. At the end of the experiment, blood was collected at low altitude. Erythrocyte deformability and aggregation were determined by an ektacytometer, oxidant (TOS) and antioxidant (TAS) status by kits. "Kruskal Wallis Variance Analysis" and "Mann Whitney U test" were used for statistics.

Results: 

Erythrocyte deformability of LHC group was increased compared to LHALC and LLC. Deformability of LHTH group was higher than LHTL and LLTL groups. No statistically significant alterations were observed in aggregation parameters. TOS of LHTH was higher than LLTL whereas TAS of the same group was increased compared to LHTL and LLTL groups.

Conclusions: 

Living (LHC) and training at altitude (LHTH) seem more advantageous in hemorheological point of view. This study was supported by Pamukkale University Research Fund.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :OC18

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