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Acta Physiologica Congress

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Acta Physiologica 2011; Volume 203, Supplement 686
Joint Congress of FEPS and Turkish Society of Physiological Sciences
9/3/2011-9/7/2011
Istanbul, Turkey


ADAPTATONS IN RESSTANCE ARTERIES TO PRESSURE
Abstract number: S13.2

Aalkjaer1 Christian

1Department of Biomedicin, Aarhus University, 8000 Aarhus C, Denmark

In hypertension the media thickness to lumen diameter ratio of resistance arteries is increased. This structural adaptation is important for the increased peripheral resistance and for the increased pressures for cerebral autoregulation in hypertension. To provide additional information on the impact of pressure on the resistance vasculature we investigated resistance arteries and the main arteries of the legs of giraffes. Muscular resistance arteries from the lower leg, the lower neck and the neck close to the head were mounted in wire myographs for measurements of structure and contractile function. Small arteries from the brain, tongue, muscle close to the head and rete mirabillis were mounted in pressure myographs and the myogenic response determined. Intraarterial pressure was measured at the top and bottom of the main artery of the leg and the vessel visualized with ultrasound. The media thickness to lumen diameter ratio and the contractility of the muscular arteries increased the higher the transmural pressures were (i.e. the closer to the ground the arteries were taken). Arteries from rete mirabilis had no myogenic response. The other vessels had a substantial myogenic response which was maximal around 180 mmHg for the extracranial arteries and around 100 for the intracranial arteries. The main artery of the leg is equipped with a sphincter-like structure and constriction of this structure and the artery either spontaneously or to injected noradrenaline results in a viscous resistance, which likely protects the vascular system of the lower leg against an excessive transmural pressure.

To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 203, Supplement 686 :S13.2

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